MMRi62 - CAS:352693-80-2

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MMRi62

目录号 : KE7642 CAS No. : 352693-80-2 纯度 : ≥95%

Data Sheet 产品使用指南

MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock
200mg		In-stock
500mg		In-stock

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Other Forms of Rapamycin:

NCOA4 - 9a In-stock
MMRi62 In-stock
α-Vitamin E In-stock
L-Glutathione reduced In-stock
Deferoxamine mesylate In-stock

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生物活性	MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.
分子式	C₂₁H₁₅Cl₂N₃O
分子量	396.27
CAS号	352693-80-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Store at -20˚C