D8-MMAD是MMAD的氘代形式。
| 生物活性 |
D8-MMAD is a deuterated form of MMAD, which is a microtubule disrupting agent. |
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| 体外研究 |
MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity. |
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| 体内研究 |
The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |
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| 溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL (128.35 mM) * "≥" means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |
纯度： 98%
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Data Sheet
