JK-P3 - CAS:942655-44-9

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JK-P3 (Synonyms:3,4-二甲氧基-N-(5-苯基-1H-吡唑-3-基)苯甲酰胺)

目录号 : KM28177 CAS No. : 942655-44-9

JK-P3 is a potent and pan VEGFR2 inhibitor, with IC50s of 7.83 μM, 27 μM and 5.18 μM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor kinase activity in vitro. JK-P3 has anti-angiogenic activity.

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生物活性	JK-P3 is a potent and pan VEGFR2 inhibitor, with IC50s of 7.83 μM, 27 μM and 5.18 μM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor kinase activity in vitro. JK-P3 has anti-angiogenic activity.
分子式	C₁₈H₁₇N₃O₃
分子量	323.35
CAS号	942655-44-9
中文名称	JK-P3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Store at -20˚C

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