Indirubin-3′-oxime (IDR3O) 是 indirubin 的合成衍生物，是细胞周期蛋白依赖性激酶 (CDKs) 和糖原合成酶激酶3β (GSK3β) 的有效抑制剂。Indirubin-3′-oxime 直接抑制JNK的所有三种亚型 (JNK1，JNK2，JNK3) 的活性，IC50s 分别为 0.8 μM、1.4 μM 和 1 μM。Indirubin-3′-oxime 可通过激活软骨细胞中的 Wnt/β-catenin 信号来促进身高增长。
| 生物活性 |
Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes. |
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| 体外研究 |
In cerebellar granule neurons (CGNs), Indirubin-3′-oxime blocks c-Jun phosphorylation induced by potassium withdrawal and prevented CGNs from apoptosis in a dose dependent manner. |
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| 体内研究 |
Indirubin-3′-oxime (0.05 or 0.5 mg/kg; i.p.; daily for 2 or 10 weeks) enhances tibial longitudinal growth in mice without adverse changes in bone thickness parameters.
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| 分子式 |
C16H11N3O2
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| 分子量 |
277.28
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| CAS号 |
667463-82-3
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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客服小K 
客服小K
Data Sheet
