AICA Ribonucleotide
(Synonyms:5'-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖基 5'-单磷酸;5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷5-单磷酸盐;5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷 5 -单磷酸酯;5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷 5''-单磷酸酯;5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷 5'-单磷酸酯;5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷5-一磷酸盐;5''-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖基 5''-单磷酸;阿卡地新-5’-磷酸酯;核苷酸标准品)
目录号 : KG12052
CAS No. : 3031-94-5
纯度 : >95%
AICA ribonucleotide is a cell-permeable activator of AMP-activated protein kinase (AMPK). It activates AMPK in a cell-free assay when used at concentrations ranging from 1 to 500 µM. AICA ribonucleotide (100-500 µM) inhibits lipolysis and lipogenesis in primary rat adipocytes. In vivo, AICA ribonucleotide (0.5 mg/kg) increases insulin sensitivity and prevents pancreatic β-cell damage in Zucker diabetic fatty rats. AICA ribonucleotide (0.5 mg/kg) induces cardiac mobilization and myofibroblast differentiation of endogenous CD44+CD45- mesenchymal stem cells (MSCs), as well as decreases cardiac scar formation, in an aged mouse model of myocardial infarction induced by left anterior descending artery (LAD) occlusion. Formulations containing AICA ribonucleotide have been used in the treatment and prevention of cardiac ischemic injury.
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| 分子式 |
C9H15N4O8P
|
| 分子量 |
338.2
|
| CAS号 |
3031-94-5
|
| 中文名称 |
5'-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖基 5'-单磷酸
|
| 储存方式 |
-20°C
|
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Data Sheet
