Apramycin (Nebramycin II)
(Synonyms:阿布拉霉素;安普霉素;阿普拉霉素;安普;盐酸安普霉素)
目录号 : KG10980
CAS No. : 37321-09-8
纯度 : >95%
Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria.
Other Forms of Rapamycin:
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分子式 |
C21H41N5O11
|
分子量 |
539.58
|
CAS号 |
37321-09-8
|
中文名称 |
阿布拉霉素
|
储存方式 |
Store at -20°C
|