Berberine Sulfate
(Synonyms:硫酸小檗碱;硫酸氢黄连素;硫酸氢小檗碱;黄连素硫酸盐;小檗碱硫酸盐,BERBERINUMSULFATE;黄连素半硫酸盐;黄连素;硫酸黄连素;硫酸小檗碱 标准品;硫酸小蘖碱;小檗碱硫酸;鱼腥草提取物;小檗碱硫酸盐;重金属捕集剂 LX-M202)
目录号 : KG10871
CAS No. : 633-66-9
纯度 : 98%
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties.
Berberine sulfate (1.25-160 μM; 72 hours) has potential inhibitory effects on the proliferation of four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29. Berberine sulfate (1.25-160 μM; 24-72 hours) induces a time- and dose-dependent inhibition of LoVo cell growth. LoVo cells are exposure to Berberine sulfate (10-80 μM) for 24 h. Cell cycle analysis of 40 μM Berberine-treated LoVo cells by flow cytometry shows accumulation of cells in the G2/M phase.Berberine sulfate (10-80 μM) suppresses cyclin B1, cdc2 and cdc25c protein expression after 24 h, especially at the dose of 80.0 μM.
Berberine sulfate (10, 30, or 50 mg/kg/day; gastrointestinal gavage; for 10 consecutive days) inhibits the growth of human colorectal adenocarcinoma in vivo. Berberine at doses of 30 and 50 mg/kg/day taken by gastrointestinal gavage shows inhibitory rates of 33.1% and 45.3% on the human colorectal adenocarcinoma xenograft growth in nude mice.
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分子式 |
C20H19NO8S
|
分子量 |
433.43
|
CAS号 |
633-66-9
|
中文名称 |
硫酸小檗碱
|