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IACS-9571 (ASIS-P040) (Synonyms:IACS-9571)
目录号 : KG10448 CAS No. : 1800477-30-8 纯度 : 98%
Data Sheet 产品使用指南
IACS-9571 is a potent and selective inhibitor of TRIM24 and BRPF1, with IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively. IACS-9571 shows excellent cellular potency with EC50 of 50 nM. IACS-9571 (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 is a selective dual TRIM24/BRPF1 inhibitor (Kd = 1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4(1, 2) relative to TRIM24.
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分子式
C32H42N4O8S
分子量
642.76
CAS号
1800477-30-8
中文名称
IACS-9571
储存方式
Store at -20°C
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