DDP-38003 dihydrochloride
目录号 : KG10429
CAS No. : 1831167-98-6
纯度 : 98%
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.
DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue.
DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent.
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分子式 |
C21H28Cl2N4O
|
分子量 |
423.38
|
CAS号 |
1831167-98-6
|
中文名称 |
DDP-38003 (dihydrochloride)
|
储存方式 |
Store at -20°C
|