Thujopsene
(Synonyms:(-)-罗汉柏烯;罗汉柏烯;(1S,6S,10S)-2,2,6,9-四甲基三环[8.1.0.01.6]十一烷-8-烯)
目录号 : KG10380
CAS No. : 470-40-6
纯度 : >85%
Thujopsene is a sesquiterpene that has been found in T. dolabrata and has diverse biological activities. It inhibits the Na+/K+-ATPase (IC50 = 25.9 µg/ml) and cytochrome P450 (CYP) isoform CYP2B6 (Ki = 0.8 µM).Thujopsene is active against Gram-positive and Gram-negative bacteria, including S. aureus, M. luteus, and S. typhimurium (MICs = 25-50 µg/ml). It inhibits antigen-induced β-hexosaminidase release from IgE-sensitized RBL-2H3 mast cells (IC50 = 25.1 µM) and is cytotoxic to A549 non-small cell lung cancer (NSCLC) cells with an LC50 value of 35.27 µg/ml. Thujopsene induces mortality in the mites D. farniae and T. putrescentiae (LC50s = 9.82 and 10.92 µg/cm2, respectively).
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分子式 |
C15H24
|
分子量 |
204.4
|
CAS号 |
470-40-6
|
中文名称 |
(1S,6S,10S)-2,2,6,9-四甲基三环[8.1.0.01.6]十一烷-8-烯
|
储存方式 |
-20°C
|