SACLAC
目录号 : KG10370
CAS No. : 2248703-42-4
纯度 : >95%
SACLAC is an irreversible inhibitor of acid ceramidase (Ki = 97.1 nM) and a derivative of the acid ceramidase inhibitor SABRAC . It decreases levels of sphingosine-1-phosphate (S1P) and increases total ceramide levels in OCI-AML-2 acute myeloid leukemia (AML) cells when used at a concentration of 2.5 µM. SACLAC (10 and 20 µM) induces apoptosis in primary AML cells. It reduces leukemic burden in MV4-11 and U937 AML mouse xenograft models when administered at a dose of 5 mg/kg.
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| 分子式 |
C20H40ClNO3
|
| 分子量 |
378
|
| CAS号 |
2248703-42-4
|
| 储存方式 |
-20°C
|
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Data Sheet
