2,3-DCPE hydrochloride
(Synonyms:2,3-十一氢盐酸盐)
目录号 : KG10284
CAS No. : 418788-90-6
纯度 : 98%
2,3-DCPE is a proapoptotic compound with selectivity for cancer cells versus normal human cells. It induces apoptosis in vitro in various cancer cell lines (IC50s = 0.89-2.69 µM) more effectively than in normal human fibroblasts (IC50 = 12.6 µM). 2,3-DCPE down-regulates Bcl-xL, however forced overexpression of Bcl-xL is sufficient to block 2,3-DCPE apoptosis induction. 2,3-DCPE can induce S-phase arrest, upregulate p21, and activate ERK.
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分子式 |
C11H15Cl2NO2.HCl
|
分子量 |
300.61
|
CAS号 |
418788-90-6
|
中文名称 |
2,3-十一氢盐酸盐
|
储存方式 |
Desiccate at -20°C
|