IM-156 (acetate)
目录号 : KG10137
CAS No. : 2043654-54-0
纯度 : 98%
IM-156 is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50 = 2.2 µM) and an activator of AMP-activated protein kinase α (AMPKα). It reduces the oxygen consumption rate (OCR; IC50 = 3.3 µM) and decreases mitochondrial ATP production in Eµ-Myc mouse lymphoma cells. IM-156 (10, 30, and 50 µM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg. It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.
Other Forms of Rapamycin:
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分子式 |
C13H16F3N5O.XC2H4O2
|
分子量 |
315.3
|
CAS号 |
2043654-54-0
|
储存方式 |
-20°C
|