α-hydroxy Tamoxifen
(Synonyms:2-(叔丁基二甲基硅氧基)乙胺;a-羟基他莫昔芬)
目录号 : KCM15950
CAS No. : 97151-02-5
纯度 : ≥98%
Tamoxifen is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. α-hydroxy Tamoxifen is a reactive metabolite of tamoxifen that is formed by the action of cytochrome P450 3A4 in human liver. It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.
Other Forms of Rapamycin:
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| 分子式 |
C26H29NO2
|
| 分子量 |
387.5
|
| CAS号 |
97151-02-5
|
| 中文名称 |
a-羟基他莫昔芬
|
| 储存方式 |
-20°C
|
客服小K 
客服小K
Data Sheet
