NS 9283
(Synonyms:3-(3-(吡啶-3-基)-1,2,4-噁二唑-5-基)苯甲腈)
目录号 : KCM15735
CAS No. : 913830-15-6
纯度 : ≥98%
NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs (EC = 4 μM). In vivo, NS 9283 potentiates ABT-594 analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis. It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg.
Other Forms of Rapamycin:
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| 分子式 |
C14H8N4O
|
| 分子量 |
248.23968
|
| CAS号 |
913830-15-6
|
| 中文名称 |
NS 9283
|
| 储存方式 |
-20°C
|
客服小K 
客服小K
Data Sheet
