Tazobactam (sodium salt)
(Synonyms:他唑巴坦钠;冻干无菌粉;泰唑巴坦钠;[2S-(2a,3b,5a)]-3-甲基-7-氧代-3-(1H-1,2,3-三氮唑-1-基甲基)-4-硫代-1-氮杂双环[3,2,0]庚烷-2-羧酸钠 4,4-二氧化物;三唑巴坦钠;他唑巴坦酸钠盐;他唑巴坦钠 (标准品);他唑巴坦钠 GMP;[2S-(2α,3β,5α)]-3-甲基-7-氧;4-羟基芬司匹利;他唑巴坦钠,AR;他唑巴坦钠标准品)
目录号 : KCM15648
CAS No. : 89785-84-2
纯度 : ≥95%
Tazobactam is a β-lactamase inhibitor with greater activity against Ambler class A serine penicillinases and class C cephalosporinases, including TEM-1, SHV-1, and P99 (ICs = 97, 150, and 8.5 nM) than class B metallo-β-lactamases and the class D oxacillinase OXA-1 (ICs = 400,000 and 1,400 nM, respectively). However, it also inhibits the class D oxacillinase OXA-2 (IC = 10 nM). Tazobactam, in combination with piperacillin, is active against Gram-positive (MICs = 2-128 µg/ml) and Gram-negative bacteria (MICs = 4-128 µg/ml). In a neutropenic mouse model of thigh infection, tazobactam potentiates the activity of ceftolozane against Enterobacteriaceae. Formulations containing tazobactam, alone and in combination with piperacillin, have been used in the treatment of β-lacatamase-producing bacteria.
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分子式 |
C10H11N4O5S.Na
|
分子量 |
322.3
|
CAS号 |
89785-84-2
|
中文名称 |
他唑巴坦钠
|
储存方式 |
-20°C
|