BIP-135 - CAS:941575-71-9

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BIP-135

目录号 : KM6051 CAS No. : 941575-71-9 纯度 : 98%

BIP-135 是一个高效、选择性的，ATP 竞争性的 GSK-3 抑制剂，对 GSK-3α 和 GSK-3β 作用的IC₅₀ 值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。

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1mg		In-stock
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC₅₀s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.

体外研究

BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations.
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress.

Western Blot Analysis

Cell Line:	Human SMA fibroblasts
Concentration:	20 μM, 25 μM, 30 μM
Incubation Time:	72 hours
Result:	Led to a 7-fold increase in SMN levels at 25 μM.

体内研究

BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight).
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy.

Animal Model:	Male and female SMN2, SMN2Δ7, Smn mice
Dosage:	75 mg/kg
Administration:	Intraperitoneal injection; daily; from postnatal day 0 to 21
Result:	Caused a modest extension in the median survival of SMA KO animals by two days.