M8-B (hydrochloride)
(Synonyms:M8-B盐酸盐)
目录号 : KCM15594
CAS No. : 883976-12-3
纯度 : ≥98%
M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (ICs = 7.8, 26.9, and 64.3 nM, respectively). It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice.
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分子式 |
C22H24N2O3S.HCl
|
分子量 |
396.54
|
CAS号 |
883976-12-3
|
中文名称 |
M8 B hydrochloride
|
储存方式 |
-20°C
|