DuP-697
(Synonyms:5-溴-2-(4-氟苯基)-3-(4-甲基磺酰基苯基)噻吩;中文名称暂缺)
目录号 : KCM15581
CAS No. : 88149-94-4
纯度 : ≥98%
DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1. The IC values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively. The IC for the inhibition of human recombinant COX-1 after the same time intervals is 9 µM. DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.
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| 分子式 |
C17H12BrFO2S2
|
| 分子量 |
411.3
|
| CAS号 |
88149-94-4
|
| 中文名称 |
Dup-697
|
| 储存方式 |
-20°C
|
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Data Sheet
