Methoxy-X04
(Synonyms:Methoxy-X04)
目录号 : KCM15494
CAS No. : 863918-78-9
纯度 : ≥95%
Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid. It displays high in vitro binding affinity (K = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease. For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging. Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.
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| 分子式 |
C23H20O3
|
| 分子量 |
344.4
|
| CAS号 |
863918-78-9
|
| 中文名称 |
Methoxy-X04
|
| 储存方式 |
-20°C
|
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Data Sheet
