SKF 86466 (hydrochloride)
目录号 : KCM15478
CAS No. : 86129-54-6
纯度 : ≥98%
SKF 86466 is an antagonist of α-adrenergic receptors (α-ARs; Ks = 9.4, 16, and 20 nM for α, α, and α receptors, respectively). It is selective for α-ARs over α-ARs (Ks = 449, 485, and 126 nM for α, α, and α receptors, respectively). SKF 86466 inhibits contractions in rabbit aorta and canine saphenous vein induced by norepinephrine or B-HT 920 , respectively (Ks = 600 and 42 nM, respectively). It decreases diastolic blood pressure in DOCA-salt hypertensive, spontaneously hypertensive, and two kidney-one clip (2K-1C) renal hypertensive rats when administered at a dose of 2 mg/kg, i.v. SKF 86466 (1 mg/kg) reduces muscle rigidity induced by reserpine in a mouse model of Parkinson’s disease.
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分子式 |
C11H14ClN.HCl
|
分子量 |
195.74
|
CAS号 |
86129-54-6
|
储存方式 |
-20°C
|