Prochlorperazine (maleate)
(Synonyms:马来酸丙氯拉嗪;普鲁氯嗪二马来酸盐;丙氯拉嗪马来酸氢盐;丙氯拉嗪;马来酸丙氯拉嗪标准品(JP);马来酸甲哌氯丙嗪;马来酸康帕嗪;马来酸氯吡嗪;马来酸氯内嗪;马来酸普鲁氮哌嗪;马来酸普鲁氯哌嗪;马来酸普鲁氯嗪;2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪二马来酸盐)
目录号 : KCM15402
CAS No. : 84-02-6
纯度 : ≥98%
Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively. It also binds to rat recombinant D3 receptors expressed in CHO cells (Ki = 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT3 in N1E-115 mouse neuroblastoma cell membranes (Ki = 1,200 nM). Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M1 muscarinic receptor. It also inhibits emesis induced by apomorphine in dogs (ED50 = 0.34 mg/kg). Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.
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分子式 |
C20H24ClN3S.2C4H4O4
|
分子量 |
606.1
|
CAS号 |
84-02-6
|
中文名称 |
马来酸丙氯拉嗪
|
储存方式 |
-20°C
|