(±)-Camphene
(Synonyms:莰烯;樟脑萜;莰芬;2,2-二甲基-3-亚甲基二环[2,2,1]庚烷;莰烯(标准品);2,2-二甲基-3-亚甲基二环[2.2.1]庚烷;坎芬;樟烯)
目录号 : KCM15274
CAS No. : 79-92-5
纯度 : ≥97%
(±)-Camphene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has diverse biological activities, including antiproliferative, pro-apoptotic, hypolipidemic, and insecticidal properties. It inhibits proliferation of B16/F10-Nex2 mouse melanoma, as well as human A2058 melanoma, HL-60 leukemia, U87MG glioblastoma, and SK-BR-3 breast cancer cells (ICs = 71.2, 35.2, 27, 55.4, and 34.7 μg/ml, respectively). (±)-Camphene (70 μg/ml) increases caspase-3 activity and induces apoptosis and endoplasmic reticulum stress in B16/F10-Nex2 cells. It lowers plasma levels of total cholesterol, LDL cholesterol, and triglycerides (TGs) in a Triton WR-1339-induced rat model of hyperlipidemia when administered at a dose of 1.5 μg/g. Dietary administration of (±)-camphene (0.2%) also inhibits hepatic steatosis and insulin resistance in a mouse model of high-fat diet-induced obesity. It also has larvicidal activity against third instar H. armigera larvae (LC = 10.64 μg/ml) and ovicidal activity against H. armigera eggs (EC = 35.39 μg/ml). Formulations containing (±)-camphene have been used as perfume and food additives.
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分子式 |
C10H16
|
分子量 |
136.23404
|
CAS号 |
79-92-5
|
中文名称 |
莰烯
|
储存方式 |
-20°C
|