CAY10434
目录号 : KCM15177
CAS No. : 769917-29-5
纯度 : ≥98%
20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. Alkylaryl imidazoles have been previously shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis. CAY10434 is a selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC value of 8.8 nM when tested in human renal microsomes. CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.
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| 分子式 |
C17H25N3O
|
| 分子量 |
287.4
|
| CAS号 |
769917-29-5
|
| 中文名称 |
CAY10434
|
| 储存方式 |
-20°C
|
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Data Sheet
