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Xamoterol (hemifumarate) (Synonyms:富马酸扎莫特罗;1-(对羟苯氧基)-3-[2-(吗啉酰胺基)乙氨基]-2-丙醇半富马酸盐;半富马酸扎莫特罗;(+/-)-N-[2-[[羟基-3-(4-羟基)丙基]氨基]乙基-4-吗啉羧酰胺 hemifumarate salt)
目录号 : KCM15035 CAS No. : 73210-73-8 纯度 : ≥98%
Data Sheet 产品使用指南
Xamoterol is a partial agonist of β-adrenergic receptors (β-ARs) with an EC value of 80 nM for the generation of cyclic AMP (cAMP) in neonatal rat cardiomyocyte cultures. It increases spontaneous contraction of isolated rat right atria (EC = 4.67 nM). In vivo, xamoterol increases heart rate in beagle dogs (ED = 3.2 µg/kg) and in a rat model of spontaneous heart failure (ED = 6 µg/kg), an effect that is reversed by the selective β-AR antagonist betaxolol but not the selective β-AR antagonist ICI 118551 . Formulations containing xamoterol have been used in the treatment of heart failure.
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分子式
C16H25N3O5.1/2C4H4O4
分子量
339.38692
CAS号
73210-73-8
中文名称
富马酸扎莫特罗
储存方式
-20°C
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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