Fialuridine
(Synonyms:非阿尿苷;1-[(2R,3S,4R,5R)-3-氟-4-羟基-5-(羟甲基)氧杂环戊-2-基]-5-碘嘧啶-2,4-二酮;1-(2-脱氧-2-氟-β-D-阿拉伯呋喃基)-5-碘尿嘧啶;【5-修饰核苷】非阿尿苷;1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil 1-(2-脱氧-2-氟-β-D-阿拉伯呋喃基)-5-碘尿嘧啶;扎鲁司特;5-碘-2'-氟脱氧尿苷)
目录号 : KCM14855
CAS No. : 69123-98-4
纯度 : ≥98%
Fialuridine (FIAU) is a nucleoside analog with antiviral activity. It inhibits thymidine kinases from herpes simplex virus types 1 and 2 with K values of 0.14 and 0.95 µM, respectively, while blocking green monkey Vero cell thymidine kinase less effectively (K = 53 µM). FIAU blocks DNA synthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex. Notably, while FIAU has few adverse effects in several mammals, it causes mitochondrial toxicity leading to liver damage and death in humans.
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| 分子式 |
C9H10FIn2O5
|
| 分子量 |
372.1
|
| CAS号 |
69123-98-4
|
| 中文名称 |
非阿尿苷
|
| 储存方式 |
-20°C
|
客服小K 
客服小K
Data Sheet
