Lasofoxifene
(Synonyms:拉索昔芬;(5R,6S)-5,6,7,8-四氢-6-苯基-5-(4-(2-(1-吡咯烷基)乙氧基)苯基)-2-萘酚;埃替拉韦;拉索昔芬-D4)
目录号 : KCM12092
CAS No. : 180916-16-9
纯度 : ≥98%
Lasofoxifene is a third-generation, non-steroidal selective estrogen receptor modulator (SERM). It selectively binds to human ERα with an IC value of 1.5 nM and inhibits bone loss in ovariectomized rats. In clinical studies of postmenopausal osteoporosis, 0.5 mg/day lasofoxifene was associated with reduced risks of nonvertebral and vertebral fractures, ER-positive breast cancer, coronary heart disease, and stroke but an increased risk of venous thromboembolic events. Lasofoxifene has also been shown to act as an inverse agonist at the CB cannabinoid receptor, indicating its potential to be repurposed as a therapeutic for indications wherein CB is a target.
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| 分子式 |
C28H31NO2
|
| 分子量 |
413.6
|
| CAS号 |
180916-16-9
|
| 中文名称 |
拉索昔芬
|
| 储存方式 |
-20°C
|
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客服小K
Data Sheet
