Ethopropazine is a butyrylcholinesterase (BChE) inhibitor (IC = 15.14 µM in human erythrocyte lysates). It is selective for BChE over acetylcholinesterase (AChE) at 500 µM. Ethopropazine also binds to rat forebrain and hindbrain membrane preparations (Ks = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M and M muscarinic acetylcholine receptors, respectively. Ethopropazine (0.232 mg/kg) decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with the adenosine A receptor antagonist ZM 241395 . It reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation when administered at doses of 20 and 30 mg/kg. Formulations containing ethopropazine were previously used in the treatment of Parkinson’s disease.