CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor.
体外研究
CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP.
体内研究
CGP-60474 (10 mg/kg; i.p.) inhibits the IL-6 level and increases the survival rate in the LPS endotoxemia model.
Animal Model:
C57Bl/6 mice (LPS endotoxemia model)
Dosage:
10 mg/kg
Administration:
I.p.
Result:
Had a higher survival rate.
分子式
C18H18N5OCl
分子量
355.82
CAS号
164658-13-3
运输条件
Room temperature in continental US; may vary elsewhere.