NH-3 - CAS:447415-26-1 - KKL Med Inc.

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NH-3

目录号 : KM21974 CAS No. : 447415-26-1

Data Sheet 产品使用指南

NH-3 是一种具有口服活性的，可逆甲状腺激素受体 (THR) 拮抗剂，IC₅₀ 为 55 nM。NH-3 是选择性甲状腺素 GC-1 的衍生物，可抑制甲状腺激素与其受体的结合，并抑制辅因子募集。

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生物活性	NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC₅₀ of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.
体内研究	NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose.
分子式	C₂₈NO₆H₂₇
分子量	473.52
CAS号	447415-26-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.