(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis.
体内研究
(-)-Hydroxycitric acid lactone (1000-3000mg/kg; fed for a period of 4 weeks) significantly decreases body weight at 2000 and 3000 mg/kg in chicken.
Animal Model:
1-day-old male broiler chickens
Dosage:
1000, 2000, 3000 mg/kg
Administration:
Fed for a period of 4 weeks
Result:
Body weight and average daily gain (ADG) in the 2000 mg/kg and 3000 mg/kg were significantly lower.
分子式
C6H6O7
分子量
190.11
CAS号
27750-13-6
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vitro:
DMSO : 250 mg/mL (1315.03 mM; Need ultrasonic)
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
5.2601 mL
26.3006 mL
52.6011 mL
5 mM
1.0520 mL
5.2601 mL
10.5202 mL
10 mM
0.5260 mL
2.6301 mL
5.2601 mL
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: