D-Leucine 具有抗癫痫活性，比L-leucine 活性高。D-leucine 能有效终止癫痫发作。体外，D-Leucine可降低长期点位，但基底突触传递无影响。
| 生物活性 |
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro. |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体外研究 |
In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes. |
||||||||||||
| 分子式 |
C6H13NO2
|
||||||||||||
| 分子量 |
131.17
|
||||||||||||
| CAS号 |
328-38-1
|
||||||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||
| 储存方式 |
|
||||||||||||
| 溶解性数据 |
In Vitro:
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble) |
纯度： ≥98%
客服小K 
客服小K
Data Sheet
