17α-Methyltestosterone - CAS:58-18-4

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17α-Methyltestosterone (Synonyms:Methyltestosterone; 17-Methyltestosterone)

目录号 : KM19025 CAS No. : 58-18-4 纯度 : 98%

Data Sheet 产品使用指南

17α-Methyltestosterone (Methyltestosterone) 是一种合成的雄激素，对雄激素受体具有高亲和力。17α-Methyltestosterone 还是竞争性的芳香酶 (aromatase) 抑制剂。

规格	价格	是否有货
100mg		In-stock
1g		In-stock
5g	询价	In-stock
10g	询价	In-stock

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生物活性

17α-Methyltestosterone (Methyltestosterone) is a synthetic androgen with affinity for the androgen receptor. 17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture.

体外研究

17α-Methyltestosterone has the IC₅₀s of 40.85±0.904 µM and 47.58±0.792 µM for MCF-7 and BT-20 cells, respectively.

Cell Viability Assay

Cell Line:	Michigan cancer foundation-7 (MCF-7) and BT-20 cells
Concentration:	0, 5, 10, 20, 30, 40, 60 µM
Incubation Time:	24 hours
Result:	Had IC₅₀s of 40.85±0.904 µM and 47.58±0.792 µM in MCF-7 and BT-20 cells, respectively.

体内研究

When BALBic mice were treated with 5 mg/kg of 17α-Methyltestosterone for 10 months the major effect is the development of hepatocytic dysplasia in all animals. The lesion appeared to be more severe in male than in female mice.

Animal Model:	Male and female BALB/c mice
Dosage:	5 mg/kg
Administration:	Treated orally for 10 months
Result:	All male mice showed at least a moderate degree of dysplasia, and 55/78 male mice developed severe dysplasia, whereas only 8/71 female mice showed dysplasia of this severity.

分子式

C₂₀H₃₀O₂

分子量

302.45

CAS号

58-18-4

中文名称

17α-甲基睾丸酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 50 mg/mL (165.32 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3063 mL	16.5317 mL	33.0633 mL
5 mM	0.6613 mL	3.3063 mL	6.6127 mL
10 mM	0.3306 mL	1.6532 mL	3.3063 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.27 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.27 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。