Neuropeptide Y (13-36), amide, human - CAS:122341-40-6

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Neuropeptide Y (13-36), amide, human (Synonyms:Neuropeptide Y (13-36, human))

目录号 : KM17865 CAS No. : 122341-40-6

Neuropeptide Y (13-36), amide, human 是选择性的神经肽 Y₂ 受体 (neuropeptide Y₂ receptor) 的激动剂。

规格	价格	是否有货	数量
500μg		In-stock
1mg		In-stock
5mg		In-stock

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生物活性

Neuropeptide Y (13-36), amide, human is a selective neuropeptide Y₂ receptor agonist.

体内研究

Neuropeptide Y (13-36) (intraventricular injection; 25-3000 pmol) produces a dose-dependent increase (up to 14%; ED₅₀ value of 0.3 nmol for overall effects and 0.97 nmol for the peak effects) in mean arterial blood pressure in the awake, unrestrained male rat without affecting heart rate. Central administration of porcine Neuropeptide Y (13-36) produces marked vasodepressor and bradycardic actions in the anaesthetized α-chloralose and in the awake unrestrained male rat.
Neuropeptide Y (13-36) (intracerebroventricular injection; 50 ng; alone; injected 30 and 15 min before measurements) injected into naïve mice impairs social novelty preference, but not sociability, and this effect is inhibited by the NPY Y₂ receptor antagonist BIIE 0246.

Animal Model:	Male ICR mice (age 4-7 weeks)
Dosage:	50 ng/mouse
Administration:	Intracerebroventricular injection
Result:	Significantly decreased interaction time with the new stranger mouse in session 3 that NPY 13-36.