Butylhydroxyanisole - CAS:25013-16-5

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Butylhydroxyanisole (Synonyms:丁基羟基茴香醚; Butylated hydroxyanisole; BHA; E320)

目录号 : KM15488 CAS No. : 25013-16-5 纯度 : 98%

Data Sheet 产品使用指南

Butylhydroxyanisole (Butylated hydroxyanisole) 是一种抗氧化剂，用作食品防腐剂。Butylhydroxyanisole 能介导肝毒性、生殖器官发育和学习迟缓以及睡眠不足。Butylhydroxyanisole 具有神经毒性，能导致大脑和神经发育中断。Butylhydroxyanisole 也是一个铁死亡 (ferroptosis) 诱导剂。

规格	价格	是否有货
500mg		In-stock
1g		In-stock
5g	询价	In-stock
10g	询价	In-stock

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Other Forms of Rapamycin:

Kgp-IN-1 hydrochloride In-stock
Ginkgolide A In-stock
Ginkgetin In-stock
VKGILS-NH2 In-stock
7,3',4'-Tri-O-methylluteolin In-stock

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生物活性

Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development. Butylhydroxyanisole is a ferroptosis inducer.

体外研究

Butylhydroxyanisole exerts neurotoxic effects by promoting cytosolic calcium accumulation and endoplasmic reticulum stress in astrocytes.
Butylhydroxyanisole (25-100 μM; 48 hours) inhibits growth and induces death in human astrocytes.
Butylhydroxyanisole (100 μM; 48 hours) decreases the expression of cell-cycle-related proteins and increased the expression of the cell cycle inhibitory protein.
Butylhydroxyanisole (100 μM; 48 hours) mediates apoptotic signals in NHA-SV40LT Cells.
Butylhydroxyanisole also increases the cytosolic calcium level and the expression of endoplasmic reticulum stress proteins.
Butylhydroxyanisole induces testicular dysfunction in mouse testis cells by dysregulating calcium homeostasis and stimulating endoplasmic reticulum stress.

Cell Proliferation Assay

Cell Line:	NHA-SV40LT cells
Concentration:	0 μM, 25 μM, 50 μM, 75 μM, 100 μM
Incubation Time:	48 hours
Result:	Exerted antiproliferative effects.

Cell Cycle Analysis

Cell Line:	NHA-SV40LT cells
Concentration:	100 μM
Incubation Time:	48 hours
Result:	Downregulated the typical cell proliferative signaling pathways, phosphoinositide 3-kinase/protein kinase B and extracellular signal-regulated kinase 1/2.

Apoptosis Analysis

Cell Line:	NHA-SV40LT cells
Concentration:	100 μM
Incubation Time:	48 hours
Result:	Increased the levels of pro-apoptotic proteins, such as BAX, cytochrome c, cleaved caspase 3, and cleaved caspase 9, and decreased the level of anti-apoptotic protein BCL-XL.

Western Blot Analysis

Cell Line:	NHA-SV40LT cells
Concentration:	100 μM
Incubation Time:	48 hours
Result:	Increased the expression of pro-apoptotic proteins and decreased the levels of anti-apoptotic proteins. Asterisks show significant effects.

体内研究

Butylhydroxyanisole (200 mg/kg; i.g.; daily; for three days) induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice.

Animal Model:	Five-week-old C57BL/6 mice (WT and Nrf2)
Dosage:	200 mg/kg
Administration:	Oral gavage, daily, for three days
Result:	Increased Nqo1 staining in hepatocytes, predominately in the pericentral region.

分子式

C₁₁H₁₆O₂

分子量

180.24

CAS号

25013-16-5

中文名称

丁基羟基茴香醚；叔丁基对羟基茴香醚；丁基大茴醚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (554.82 mM)

H₂O : 1 mg/mL (5.55 mM; ultrasonic and warming and heat to 60°C)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.5482 mL	27.7408 mL	55.4816 mL
5 mM	1.1096 mL	5.5482 mL	11.0963 mL
10 mM	0.5548 mL	2.7741 mL	5.5482 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

临床试验

科研文献

纯度： 98%

Data Sheet

产品使用指南

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稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 5 篇科研文献

The molarity calculator equation

The dilution calculator equation