Albiflorin - CAS:39011-90-0

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Albiflorin (Synonyms:芍药内酯苷)

目录号 : KM14496 CAS No. : 39011-90-0 纯度 : ≥98%

Albiflorin 是牡丹根中的主要成分，是一种具有神经保护作用的单萜糖苷。Albiflorin 还具有抗炎，抗氧化和缓解疼痛作用。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Albiflorin, a major constituent contained in peony root, is a monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects.

体外研究

Albiflorin (50-200 μM; pretreated for 3 hours; PC12 cells) treatment significantly ameliorates glutamate (Glu)-induced reduction of cell viability.
Albiflorin (100 μM; pretreated for 3 hours; PC12 cells) treatment significantly ameliorates Glu-induced reduction of nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio.
Albiflorin (100 μM; pretreated for 3 hours; PC12 cells) treatment enhances phosphorylation of AKT and its downstream element GSK-3β.

Cell Viability Assay

Cell Line:	PC12 cells
Concentration:	50 μM, 100 μM, 200 μM
Incubation Time:	Pretreated for 3 hours
Result:	Significantly ameliorated Glu-induced reduction of cell viability.

Apoptosis Analysis

Cell Line:	PC12 cells
Concentration:	100 μM
Incubation Time:	Pretreated for 3 hours
Result:	Significantly ameliorated Glu-induced reduction of nuclear and mitochondrial apoptotic alteration.

Western Blot Analysis

Cell Line:	PC12 cells
Concentration:	100 μM
Incubation Time:	Pretreated for 3 hours
Result:	Enhanced phosphorylation of AKT and its downstream element GSK-3β.

体内研究

Albiflorin (50 mg/kg; intraperitoneal injection; once a day; for 15 days; Wistar rats) treatment significantly increases the paw withdrawal threshold (PWT) on the 11th and 15th day after surgery in rats. Albiflorin could inhibit the activation of p38 MAPK pathway in spinal microglia and subsequent upregulated IL-1β and TNF-α. Albiflorin displays remarkable effects on inhibiting the activation of astrocytes, suppressing the overelevated expression of phosphorylation of c-JNK (p-JNK) in astrocytes, and decreasing the content of chemokine CXCL1 in the spinal cord.

Animal Model:	Wistar rats (7-week-old; 200-220 g) bearing chronic constriction injury (CCI)
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection; once a day; for 15 days
Result:	Significantly increased the paw withdrawal threshold (PWT) on the 11th and 15th day after surgery.

分子式

C₂₃H₂₈O₁₁

分子量

480.46

CAS号

39011-90-0

中文名称

芍药内酯苷；白芍药苷；白芍苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (208.13 mM)

H₂O : 100 mg/mL (208.13 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0813 mL	10.4067 mL	20.8134 mL
5 mM	0.4163 mL	2.0813 mL	4.1627 mL
10 mM	0.2081 mL	1.0407 mL	2.0813 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.20 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.20 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.20 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

纯度： ≥98%

Data Sheet

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