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Glutamate-cysteine ligase inhibitor EN25
目录号 : KP26969 CAS No. : 1647534-29-9
规格 价格 是否有货 数量
50mg 询价 In-stock

Other Forms of Rapamycin:

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生物活性

Glutamate-cysteine ligase inhibitor EN25 is a covalent inhibitor of the glutamate-cysteine ligase (GCL) with IC50 of 16 uM, targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL.
Glutamate-cysteine ligase inhibitor EN25 inhibits GCL activity, lowers cellular GSH levels, and impairs cell viability in ARID1A-deficient cancer cells that are particularly vulnerable to glutathione depletion, but not in ARID1A-positive cancer cells.

分子式
C25H24N2O2S
分子量
416.54
CAS号
1647534-29-9
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at -20˚C 

溶解性数据

10 mM in DMSO

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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