(Rac)-Modipafant - CAS:122956-68-7

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(Rac)-Modipafant (Synonyms:UK-74505)

目录号 : KM10220 CAS No. : 122956-68-7

Data Sheet 产品使用指南

(Rac)-Modipafant (UK-74505) 是一种口服的、选择性的、长效的不可逆血小板活化因子受体 (PAFR) 受体拮抗剂。(Rac)-Modipafant 预防严重登革热感染。

规格	价格	是否有货	数量
5mg		In-stock

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生物活性

(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.

体内研究

(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC₅₀=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.

Animal Model:	8- to 10-week-old BALB/c mice (DEN-2 strain infected)
Dosage:	10 mg/kg
Administration:	P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10
Result:	Decreased by approximately 50% the lethality associated with DEN-2 infection.

Animal Model:	Male BALB/C (8- to 10- week-old) wild-type mice
Dosage:	5, 10 and 20 mg/kg
Administration:	P.o.
Result:	Dose-dependently inhibited the Zymosan -induced articular hyperalgesia.

分子式

C₃₄H₂₉N₆O₃Cl

分子量

605.09

CAS号

122956-68-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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