13C17-Mycophenolic Acid - CAS:1202866-92-9

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13C17-Mycophenolic Acid (Synonyms:全部为 13C 标记的霉酚酸;霉酚酸-(全碳-13))

目录号 : KG12950 CAS No. : 1202866-92-9 纯度 : >90%

Data Sheet 产品使用指南

13C17-Mycophenolic acid is intended for use as an internal standard for the quantification of mycophenolic acid by GC- or LC-MS. Mycophenolic acid is an immunosuppressive microbial metabolite that has been found in P. brevicompactum. It is also an active metabolite of mycophenolate mofetil that is formed via carboxylesterase 1 (CES1) and CES2. Mycophenolic acid is an inhibitor of IMP dehydrogenase (IMPDH) type I and type II (IC50s = 32 and 11 nM, respectively, in cell-free assays) and inhibits DNA synthesis in L strain mouse fibroblasts when used at concentrations ranging from 0.1 to 10 µg/ml. It is active against several strains of C. albicans, C. parakrusei, C. tropicalis, and C. neoformans (MICs = 3.9-31.25 µg/ml), as well as various strains of S. aureus (MICs = 31.25-125 µg/ml). Mycophenolic acid (150 mg/kg) reduces splenomegaly in a mouse model of Friend virus-induced leukemia.6 It decreases the number of hemolytic plaque forming cells isolated from the spleen of mice immunized with sheep red blood cells (RBCs) when administered at doses ranging from 60 to 240 mg/kg. Formulations containing mycophenolic acid have been used as immunosuppressive agents in the prevention of organ transplant rejection.

规格	价格	是否有货	数量
1ml	询价	In-stock

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Other Forms of Rapamycin:

13C17-Mycophenolic Acid In-stock
Stearic Acid glycidyl ester-d5 In-stock
Fumonisin B1-13C34 In-stock
Zosuquidar In-stock
Zonisamide sodium In-stock

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生物活性	13C17-Mycophenolic acid is intended for use as an internal standard for the quantification of mycophenolic acid by GC- or LC-MS. Mycophenolic acid is an immunosuppressive microbial metabolite that has been found in P. brevicompactum. It is also an active metabolite of mycophenolate mofetil that is formed via carboxylesterase 1 (CES1) and CES2. Mycophenolic acid is an inhibitor of IMP dehydrogenase (IMPDH) type I and type II (IC50s = 32 and 11 nM, respectively, in cell-free assays) and inhibits DNA synthesis in L strain mouse fibroblasts when used at concentrations ranging from 0.1 to 10 µg/ml. It is active against several strains of C. albicans, C. parakrusei, C. tropicalis, and C. neoformans (MICs = 3.9-31.25 µg/ml), as well as various strains of S. aureus (MICs = 31.25-125 µg/ml). Mycophenolic acid (150 mg/kg) reduces splenomegaly in a mouse model of Friend virus-induced leukemia.6 It decreases the number of hemolytic plaque forming cells isolated from the spleen of mice immunized with sheep red blood cells (RBCs) when administered at doses ranging from 60 to 240 mg/kg. Formulations containing mycophenolic acid have been used as immunosuppressive agents in the prevention of organ transplant rejection.
分子式	[₁₃C]₁₇H₂₀O₆
分子量	337.2
CAS号	1202866-92-9
中文名称	Mycophenolic acid-13C17 solution
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Store at -20°C