Apatinib-d8 - CAS:2468771-43-7

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Apatinib-d8

目录号 : KG12948 CAS No. : 2468771-43-7 纯度 : >97%

Data Sheet 产品使用指南

Apatinib-d8 is intended for use as an internal standard for the quantification of apatinib by GC- or LC-MS. Apatinib is a tyrosine kinase inhibitor that potently suppresses the kinase activity of vascular endothelial growth factor 2 (VEGFR2; IC50 = 1 nM). It is less effective against c-Kit (IC50 = 429 nM), RET (IC50 = 13 nM), and c-Src (IC50 = 53 nM) and does not inhibit EGFR, HER2, or FGFR1 (IC50s = >10 µM). Apatinib has been shown to inhibit the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) stimulated by fetal bovine serum and, either alone or in combination with chemotherapeutic agents, prevents the growth of several established human tumor xenograft models.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock

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Other Forms of Rapamycin:

Lamotrigine-d3 In-stock
Apatinib-d8 In-stock
BRD5631 In-stock
AMDE-1 In-stock
MDK-6983 In-stock

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生物活性	Apatinib-d8 is intended for use as an internal standard for the quantification of apatinib by GC- or LC-MS. Apatinib is a tyrosine kinase inhibitor that potently suppresses the kinase activity of vascular endothelial growth factor 2 (VEGFR2; IC50 = 1 nM). It is less effective against c-Kit (IC50 = 429 nM), RET (IC50 = 13 nM), and c-Src (IC50 = 53 nM) and does not inhibit EGFR, HER2, or FGFR1 (IC50s = >10 µM). Apatinib has been shown to inhibit the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) stimulated by fetal bovine serum and, either alone or in combination with chemotherapeutic agents, prevents the growth of several established human tumor xenograft models.
分子式	C₂₄H₁₅D₈N₅O
分子量	405.5
CAS号	2468771-43-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Store at -20°C