Forphenicinol
目录号 : KG12940
CAS No. : 71522-58-2
纯度 : >90%
Forphenicinol is an immunomodulator and a derivative of the bacterial metabolite forphenicine . It increases the phagocytosis of yeast by peritoneal macrophages isolated from thioglycolate-stimulated mice. Forphenicinol (100 µg/animal) prevents cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH), as well as enhances DTH in response to the hapten oxazolone or sheep red blood cells in mice. It enhances the bactericidal activity of macrophages against P. aeruginosa in mice when administered at a dose of 0.5 mg/kg. Forphenicinol (15.6-1,000 µg/animal) increases survival in a mouse model of P. aeruginosa infection. It also inhibits tumor growth in S180 sarcoma and IMC carcinoma mouse xenograft models when administered at doses ranging from 0.05 to 5 mg/kg per day.
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生物活性 |
Forphenicinol is an immunomodulator and a derivative of the bacterial metabolite forphenicine . It increases the phagocytosis of yeast by peritoneal macrophages isolated from thioglycolate-stimulated mice. Forphenicinol (100 µg/animal) prevents cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH), as well as enhances DTH in response to the hapten oxazolone or sheep red blood cells in mice. It enhances the bactericidal activity of macrophages against P. aeruginosa in mice when administered at a dose of 0.5 mg/kg. Forphenicinol (15.6-1,000 µg/animal) increases survival in a mouse model of P. aeruginosa infection. It also inhibits tumor growth in S180 sarcoma and IMC carcinoma mouse xenograft models when administered at doses ranging from 0.05 to 5 mg/kg per day.
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分子式 |
C9H11NO4
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分子量 |
197.2
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CAS号 |
71522-58-2
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运输条件 |
Room temperature in continental US; may vary elsewhere.
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储存方式 |
Store at -20°C
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