Fumonisin B1-13C34 (FB1-13C34) is intended for use as an internal standard for the quantification of FB1 by GC- or LC-MS. FB1 is a mycotoxin that has been found in F. moniliforme. It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme). FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively. It is cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 500 mg/kg for 21 days. It has been detected in corn and corn-based foods and livestock feeds.
Fumonisin B1-13C34 (FB1-13C34) is intended for use as an internal standard for the quantification of FB1 by GC- or LC-MS. FB1 is a mycotoxin that has been found in F. moniliforme. It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme). FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively. It is cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 500 mg/kg for 21 days. It has been detected in corn and corn-based foods and livestock feeds.
分子式
13C34H59NO15
分子量
755.58
CAS号
1217458-62-2
中文名称
Fumonisin B1-13C34 solution
运输条件
Room temperature in continental US; may vary elsewhere.