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Fumonisin B1-13C34 (FB1-13C34) is intended for use as an internal standard for the quantification of FB1 by GC- or LC-MS. FB1 is a mycotoxin that has been found in F. moniliforme. It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme). FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively. It is cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 500 mg/kg for 21 days. It has been detected in corn and corn-based foods and livestock feeds.

[₁₃C]₃₄H₅₉NO₁₅

755.6

1217458-62-2

Fumonisin B1-13C34 solution

Room temperature in continental US; may vary elsewhere.